AFFINIMIP® SPE for radiotracer purification is based on the affinity for the precursor. In the case of Aromatic Nucleophilic Substitution with 18F, impurities, Kryptofix and residual 18F are also retained in the cartridge, while the purified radiotracer is obtained after elution.
18F Aromatic Nucleophilic Substitution
Purification of 18F radiotracer obtained from ammonium precursor by Aromatic Nucleophilic Substitution.
AFFINIMIP® SPE 18F – Aromatic Nucleophilic Substitution is a selective solid phase extraction cartridge used to purify rapidly and perfectly a 18F radiotracer synthesized from an aromatic nucleophilic substitution. The cartridge retains the ammonium-based precursor as well as the phenol- and dialkylamino-based impurities.