Aminoglycosides are an important class of broad-spectrum antibiotics frequently used to treat bacterial infections such as some Gram -positive and mainly gram-negative bacteria. However, their use is limited due to side effects of nephrotoxicity and ototoxicity and due to antimicrobial resistance to some of these molecules.
Aminoglycosides are still frequently used for veterinary use to treat infections in cattle, pigs, sheep, goat or horses.
Nevertheless, food safety authorities have established maximum residue limits (MRLs) in several countries in Europe, China, USA, Canada or by the codex alimentarius of FAO/WHO. These MRLs are defined for a combination of molecules/matrices.